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Date: Mon, 8 Dec 1997 11:43:43 -0600
Post-doctoral position available
A post-doctoral position for an electrophysiologist is available in the
Laboratory of Neuropharmacology (J.C. Michaud, I.A. Lefevre) at Sanofi
Recherche in Montpellier (France). Experience in conventional
intracellular micro-electrode recording in brain slices is essential,
but any additional skill such as in vivo electrophysiology, imaging or
patch-clamp techniques would be advantageous.
The position is available from January 1st 1998 for 12-18 months for
French citizens (Sanofi or Elf-Aquitaine contracts); contracts of longer
duration can however be obtained for other Europeans (Elf-Aquitaine
International contracts).
The laboratory provides the electrophysiological contribution to Central
Nervous System projects, which mainly concern G-protein coupled membrane
receptors, and also include studies from other fields, including
chemistry, biochemistry, molecular biology and animal behaviour.
The major interest in the laboratory is the study of the modulation of
neuronal activity by neuropeptides (e.g., cholecystokinin, neurotensin,
tachykinins...). The development of appropriate experimental models is
also used to evaluate the effects of new non-peptide compounds, that act
as agonists or antagonists of neuropeptide receptors. The interaction
between these receptors and the various channels and receptors which
control neuronal excitability is analysed electrophysiologically at
three levels: single cells, brain slices, and anaesthetised animals. The
following selection of recently published work illustrates the diversity
of topics under investigation.
SR140333, a novel, selective and potent non-peptide antagonist of the
NK1 tachykinin receptor : characterization on the U373MG cell line.
Oury-Donat F., Lefevre I.A., Thurneyssen O., Gautier T., Bordey A.,
Feltz P., Emonds-Alt X., Le Fur G., Soubrié P. (1994) Journal of
Neurochemistry 62, 1399-1407
Antagonism by SR142801, a non-peptide NK3 receptor antagonist of
senktide-evoked increase in firing rate in guinea-pig locus coeruleus
slices. Michaud J.C., Soubrié P., Le Fur G. (1995) British
Pharmacological Society Spring Meeting, Canterbury, April 1995
La stimulation du récepteur CCKA induit des courants ioniques dans deux
lignees cellulaires (3T3-hCCKA et CHP212). Lefevre I.A. (1996) Colloque
Canaux Ioniques, 7th édition, La Londe les Maures, September 1996
Effects of selective neurotensin receptor antagonists suggest two
subtypes of neurotensin receptors in guinea-pig dopaminergic neurones.
Nalivaiko E., Michaud J.C., Soubrié P., Le Fur G. (1997) European
Neuropeptide Meeting, Marburg, May 1997
Tachykinin neurokinin-1 and neurokinin-3 receptor-mediated responses in
guinea-pig substantia nigra: an in vitro electrophysiological study.
Nalivaiko E., Michaud J.C., Feltz P., Soubrié P., Le Fur G. (1997)
Neuroscience 78 (3)745-757.
Effects of SR140333, a selective non-peptide NK1 receptor antagonist, on
trigemino-thalamic nociceptive pathways in the rat. Michaud J.C., Alonso
R., Gueudet C., Fournier M., Calassi R., Brelière J.C., Le Fur G.,
Soubrié P. Fundamental and Clinical Pharmacology, in press.
For further information contact isabel.lefevre_at_tls1.elfsanofi.fr
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Received on Tue Mar 11 1997 - 12:07:51 PST
